Publications

These are publications authored by members of the lab.

2009

TcSNP: a database of genetic variation in Trypanosoma cruzi.
Alejandro Ackermann, Santiago Carmona and Fernán Agüero.
Nucleic Acids Research 37: D541-D544.
DOI:10.1093/nar/gkn874, PDF

2008

A new family of developmentally regulated surface antigens in Trypanosoma cruzi identified from a subtractive trypomastigote cDNA library.
Valeria Tekiel, Fernán Agüero, Guillermo Bernabó and Daniel O Sánchez.
Submitted.

Genomic-scale prioritization of drug targets: the TDR Targets Database.
Fernán Agüero, Bissan Al-Lazikani, Matthew Berriman, Frederick S. Buckner, Robert K. Campbell, Santiago Carmona, Feng Chen, Gregory J. Crowther, Christiane Hertz-Fowler, Andrew L. Hopkins, Gregg McAllister, Solomon Nwaka, John Overington, Arnab Pain, Gaia V. Paolini, Ursula Pieper, Stuart A. Ralph, Aaron Riechers, David S. Roos, Andrej Sali, Dhanasekaran Shanmugam, Takashi Suzuki, Wesley C. Van Voorhis, Christophe L. Verlinde.
Nature Reviews Drug Discovery 7: 900-907.
PubMed, DOI: 10.1038/nrd2684

2007

Galectin-8 induces apoptosis in the CD4^high CD8^high thymocyte subpopulation.
Tribulatti MV, Mucci J, Cattaneo V, Agüero F, Gilmartin T, Head SR, Campetella O.
Glycobiology 17: 1404-12
DOI: 10.1093/glycob/cwm104

The Calcineurin A homologue from Trypanosoma cruzi lacks two important regulatory domains.
Valeria Ruiz Moreno, Fernán Agüero, Valeria Tekiel and Daniel O Sánchez.
Acta Tropica: 101: 80-89.
DOI: 10.1016/j.actatropica.2006.11.008

Two metallocarboxypeptidases of the protozoan Trypanosoma cruzi belong to the M32 family, found so far only in prokaryotes.
Gabriela Niemirowicz, Fernán Agüero, Fabiola Parussini and Juan José Cazzulo.
Biochemical Journal 401: 399-410
Full text (publisher)

Dynamics of a hepatitis B virus e antigen minus population ascribed to genotype F during the course of a chronic infection despite the presence of anti-HBs antibodies.
Mathet VL, Lopez JL, Ruiz V, Sanchez DO, Carballal G, Campos RH, Oubina JR.
Virus Research 123: 72-85.

2006

TcruziDB: an integrated, post-genomics community resource for Trypanosoma cruzi
Fernán Agüero, Wenlong Zheng, D. Brent Weatherly, Pablo Mendes and Jessica Kissinger.
Nucleic Acids Research 34: D428.
Full text (publisher)
DOI: 10.1093/nar/gkj108

Metacaspases of Trypanosoma cruzi: Possible candidates for programmed cell death mediators.
Gregor Kosec, Vanina Alvarez, Fernán Agüero, Daniel Sánchez, Marko Dolinar, Boris Turk, Vito Turk and Juan J. Cazzulo
Molecular and Biochemical Parasitology 145: 18.
Abstract (PubMed)  |  Full Text (publisher)

2005

The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease.
Najib El-Sayed, et al.
Science 309: 409.
Full text (publisher)

Characterization of farnesylated protein tyrosine phosphatase TcPRL-1 from Trypanosoma cruzi.
Cuevas IC, Rohloff P, Sanchez DO, Docampo R.
Eukaryotic Cell 4: 1550.
Full text (publisher)

Whole-genome analysis of speciation events in pathogenic Brucellae.
Patrick SG Chain, Diego J Comerci, Marcelo E Tolmaski, Frank W Larimer, Stephanie A Malfatti, Lisa M Vergez, Fernán Agüero, Miria L Land, Rodolfo A Ugalde and Emilio García.
Infection and Immunity 73: 8353.
Full text (publisher)

2004

Generation and analysis of expressed sequence tags from Trypanosoma cruzi trypomastigote and amastigote cDNA libraries
Fernán Agüero, Karim Ben Abdellah, Daniel O. Sánchez and Antonio González.
Molecular and Biochemical Parasitology 136: 221.
Web appendix  |  Pre-print (PDF; 62K)

Purification, cloning, and expression of the mitochondrial malate dehydrogenase (mMDH) from protoscolices of Echinococcus granulosus.
Fernán Agüero, Griselda Noé, Ulf Hellman, Yolanda Repetto, Arnaldo Zaha and Juan José Cazzulo.
Molecular and Biochemical Parasitology 137: 207.
Full text (publisher)

Gene Expression Analysis in the Hippocampal Formation of Tree Shrews Chronically Treated with Cortisol.
Julieta Alfonso, Fernán Agüero, Daniel O. Sánchez, Gabriele Flügge, Eberhard Fuchs, Alberto C. Frasch and Guido D. Pollevick.
Journal of Neuroscience Research 78: 702.
Abstract (PubMed)  |  Full text (publisher, requires subscription)

2003

gp63 homologues in Trypanosoma cruzi: surface antigens with metalloprotease activity and a possible role in host cell infection.
Cuevas IC, Cazzulo JJ, Sanchez DO.
Infecton and Immunity 71: 5739.
Full text (publisher)

Differential accumulation of mutations localized in particular domains of the mucin genes expressed in the vertebrate host stage of Trypanosoma cruzi.
Vanina Campo, Javier Di Noia, Carlos Buscaglia, Fernán Agüero, Daniel O. Sánchez and Alberto C. Frasch.
Molecular and Biochemical Parasitology 133: 81.
Full text (publisher)

Characterization of a lysosomal serine carboxypeptidase from Trypanosoma cruzi.
Fabiola Parussini, Mayra García, Juan Mucci, Fernán Agüero, Daniel O. Sánchez, Ulf Hellman, Lena Åslund and Juan José Cazzulo.
Molecular and Biochemical Parasitology, 131: 11.
Full text (publisher)

Phylogenetic and mathematical analyses for investigating putative mother-to-infant transmission chains when only GB virus C (hepatitis G virus) 5' noncoding region sequences are available.
Mathet VL, Espinola L, Ruiz V, Marincola A, Quarleri JF, Ceballos A, Peralta LA, Natal M, Haedo A, Sanchez DO, Oubina JR.
J Clinical Microbiology 41: 4489.
Full text (publisher)

2002

Gene discovery in the freshwater fish parasite Trypanosoma carassii: identification of putative trans-sialidase and mucin-like genes.
Fernán Agüero, Vanina Campo, Laura Cremona, Adriana Jäger, Javier M. Di Noia, Peter Overath, Daniel O. Sánchez and Alberto Carlos C. Frasch
Infection and Immunity, 70 (12): 7140-7144
Abstract (Entrez)  |  Web appendix  |  PDF (159 Kb)

Trypanosoma cruzi surface mucin TcMuc-e2 expressed on higher eukaryotic cells induces human T cell anergy, which is reversible.
Argibay PF, Di Noia JM, Hidalgo A, Mocetti E, Barbich M, Lorenti AS, Bustos D, Tambutti M, Hyon SH, Frasch AC, Sanchez DO.
Glycobiology 12: 25
Full text (publisher)

2001

Genomic sequencing in Brucella abortus.
Daniel O. Sánchez, Rubén Zandomeni, Silvio Cravero, Ramiro E. Verdún, Esther Pierrou, Paula Faccio, Gabriela Díaz, Silvia Lanzavecchia, Fernán Agüero, Alberto Carlos C. Frasch, Siv G. E. Andersson, Osvaldo L. Rosetti, Oscar Grau and Rodolfo Ugalde
Infection and Immunity 69 (2): 865-868.
Abstract (Entrez)  |  PDF (107 Kb)

2000

A random sequencing approach for the analysis of the Trypanosoma cruzi genome: large gene and repetitive DNA families and gene discovery.
Fernán Agüero, Ramiro E. Verdún, Alberto C. C. Frasch, and Daniel O. Sánchez
Genome Research 10(12): 1996-2000.
Abstract (Entrez)  |  PDF (2.4 Mb)

A homologue of an operon required for DNA transfer in Agrobacterium is required in Brucella abortus for virulence and intracellular multiplication.
Sieira R, Comerci DJ, Sanchez DO, Ugalde RA.
J Bacteriology 182: 4849.
Full text (publisher)

AU-rich elements in the 3'-untranslated region of a new mucin-type gene family of Trypanosoma cruzi confers mRNA instability and modulates translation efficiency.
Di Noia JM, D'Orso I, Sanchez DO, Frasch AC.
J Biological Chemistry 275: 10218.
Full text (publisher)

1999

Organization of the network for the study of the Trypanosoma cruzi genome
Alberto Carlos C. Frasch, Ramiro E. Verdún and Daniel O. Sánchez
Medicina (Buenos Aires) 59 Suppl. 2: 4-6.
Abstract (Entrez)

1998

Gene discovery through Expressed Sequence Tag sequencing in Trypanosoma cruzi.
Ramiro Verdún, Nelson Di Paolo, Turan P. Urmenyi, Edson Rondinelli, Alberto C. C. Frasch and Daniel O. Sanchez.
Infection and Immunity 66: 5393-5398.
Abstract (Entrez)  |  PDF (416 Kb)

1996

Mapping the Trypanosoma cruzi genome: analyses of representative cosmid libraries.
Hanke J, Sanchez DO, Henriksson J, Aslund L, Pettersson U, Frasch AC, Hoheisel JD.
Biotechniques 21(4): 686-8, 690-3.
Abstract (Entrez)